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Epigenetics Help Find Prognosis for Posterior Fossa Ependymomas

— Categories: Ependymoma Research Articles     Posted on January 18, 2017

Ependymomas are brain or spinal tumors that can occur in people of all ages within the central nervous system. The prognosis of these tumors does not necessarily correlate with tumor grade and there are no genetic mutations that can be used to classify these tumors.

Deriving Therapies for Children with Primary CNS Tumors Using Pharmacokinetic Modeling and Simulation of Cerebral Microdialysis Data

— Categories: Ependymoma Research Articles     Posted on June 16, 2014

The treatment of children with ependymoma and CNS tumors continues to be a challenge despite recent advances in technology and diagnostics. In this overview, St. Jude Children’s Research Hospital describes their approach for identifying and evaluating active anticancer drugs through a process that enables rational translation from the lab to the clinic.

England Article Explored Impact of Caring for Children with Brain Tumors on Mothers

— Categories: Ependymoma Research Articles     Posted on September 13, 2013

The diagnosis of a brain tumors, including ependymoma, in children can impact not only the child but the entire family. This study is a qualitative study.

A Molecular Biology and Phase II Trial of Lapatinib in Children With Refractory CNS Malignancies: A Pediatric Brain Tumor Consortium Study

— Categories: Ependymoma Research Articles     Posted on September 11, 2013

The pediatric brain tumor consortium conducted a molecular biology (MB) and phase II study to estimate inhibition of tumor ERBB signaling and sustained responses by lapatinib in children with recurrent CNS malignancies.

Study Supports the Use of Adjuvant Radiation Therapy in Management of Pediatric Myxopapillary Ependymoma

— Categories: Ependymoma Research Articles     Posted on February 18, 2013

Historically, myxopapillary ependymoma has been considered a benign neoplasm, often cured with surgical resection. However, this manuscript questions this dogma.

Adjuvant Radiotherapy Delays Recurrence Following Subtotal Resection of Spinal Cord Ependymomas

— Categories: Ependymoma Research Articles     Posted on February 15, 2013

This article represents a secondary analysis of existing published data of the impact of the extent of surgery and adjuvant radiation therapy in adults with spinal cord ependymoma.

Increased Expression of Tumor-associated Antigens in Pediatric and Adult Ependymomas: Implication for Vaccine Therapy

— Categories: Ependymoma Research Articles     Posted on January 9, 2013

A group of investigators at the University of Pittsburgh are investigating a peptide-based vaccine therapy targeting EphA2, IL-13Ra2, and Survinin for the treatment of pediatric tumors. This study explored whether these targets are overexrpressed in ependymoma as they are in other gliomas.

Pediatric Study Group Publish Paper on Lack of Efficacy of Bevacizumab Plus Irinotecan in Pediatric Recurrent Ependymoma

— Categories: Ependymoma Research Articles     Posted on November 14, 2012

This study, conducted by the Pediatric Brain Tumor Consortium, was one component of a wider effort to study the efficacy of bevacizumab in combination with a conventional chemotherapeutic agent (here irinotecan) to treat children with recurrent brain tumors.

Retrospective Evaluation of Factors Associated with Prognosis in Children Treated for Ependymoma in Australia

— Categories: Ependymoma Research Articles     Posted on September 5, 2012

A retrospective evaluation of tumor and treatment characteristics of 43 children treated for ependymoma/anaplastic ependymoma treated at New South Wales Cancer Center between 1969 and 2009.

Phase II Study of Pre-irradiation Chemotherapy For Childhood Intracranial Ependymoma

— Categories: Ependymoma Research Articles     Posted on August 21, 2012

Achieving a complete removal of the tumor before using radiation is a key factor in controlling the disease in patients with ependymoma. However, due to the tumor’s nature and location, it is difficult to achieve a complete removal of the tumor during the initial surgery without damaging the cranial nerves and surrounding brain tissue.

Two Publications Address Complications of Therapy in Children and Adults

— Categories: Ependymoma Research Articles     Posted on August 10, 2011

Two recent publications address the complications of therapy for people with ependymoma. Researchers explored the impact of location of tumor and radiation on cognitive and psychological outcomes in 23 children with ependymoma.

Maintenance and Dysfunction Predict Recurrence in Pediatric Ependymoma

— Categories: Ependymoma Research Articles     Posted on October 25, 2008

The enzymatic subunit of telomerase (hTERT) is an important prognostic marker for paediatric ependymoma. Because of the lack of good, representative pre-clinical models for ependymoma, researchers took advantage of their large cohort of ependymoma patients, some with multiple recurrences, to investigate telomere biology in these tumours.

Paediatric ependymomas: should we avoid radiotherapy?

— Categories: Ependymoma Research Articles     Posted on August 22, 2007

Although ependymomas account for only 10% of all childhood brain tumours, this tumour type is particularly common in young children. Because of the potentially severe long-term effects of radiation on the developing central nervous system, over the past 20 years, several studies have focused on the feasibility of using postoperative chemotherapy to delay or even avoiding radiotherapy.

Childhood Intracranial Ependymoma

— Categories: Ependymoma Research Articles     Posted on July 15, 2007

Because few large studies of pediatric ependymoma treatment are available, the authors believed that a retrospective review of treatment outcomes from a single institution would yield potentially valuable information regarding potential prognostic factors.

Adult Intracranial Ependymoma

— Categories: Ependymoma Research Articles     Posted on May 5, 2007

The authors report a retrospective study of 152 adult patients harbouring intracranial ependymomas from 24 French Neurosurgical Centres between 1990 and 2004. All clinico-radiological and follow-up data were analysed and a central pathologic review was performed by two confirmed neuropathologists.

Progression and Survival in Pediatric Intracranial Ependymoma

— Categories: Ependymoma Research Articles     Posted on December 13, 2006

Pediatric intracranial ependymomas are a heterogeneous group of neoplasms with unpredictable clinical and biologic behavior. As part of ongoing studies to identify potential biologic and therapeutic markers, doctors analyzed the role of human telomere reverse transcriptase (hTERT; the catalytic subunit of telomerase) expression as a prognostic marker for this disease.

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