CERN Supports Research to Further Understand Ependymoma

— Categories: CERN Research Articles     Posted on October 17, 2019

CERN fellowship recipient, Dr. Kristian Pajtler, and collaborators, have made important discoveries.

They studied YAP1 fusion-positive supratentorial ependymomas to determine the molecular mechanisms of oncogenesis (genetic changes that have the potential to cause cancer). They discovered YAP1-MAMLD1 fusion functions as an oncogenic driver of ependymoma through recruitment of TEADs and NFIs, indicating the need for preclinical studies to block the interaction between YAP1 fusions and NFI and TEAD transcription factors.

To read the Nature Article, click here.

In addition, the team recently identified a novel molecular group of spinal ependymoma with MYCN amplification and plans to establish it as a new molecular subgroup in ependymoma. 

To read the Springer Article, click here.

 

Read more about Dr. Pajtler's work

 

 

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